Table of Contents
How Does CALECIM® Reset the Menopausal Scalp for Density?
The CALECIM® Advanced Hair System addresses menopausal hair thinning by targeting the underlying cause, follicle miniaturization and chronic inflammation, with the proprietary PTT-6® complex derived from ethically sourced stem cells. This regenerative complex sends specific cellular messages to the scalp to prolong the hair’s growth phase and promote the regeneration of weak or dormant follicles.
The efficacy of the system is rooted in its scientifically demonstrated actions:
- Mechanism of Action: PTT-6® contains over 3,000 proteins, including high concentrations of growth factors (such as HGF, b-FGF, and VEGF) and exosomes, which function as paracrine signaling messengers. This signalling effectively promotes Dermal Papilla Cell (DPC) proliferation, a crucial step in regenerating the hair follicle.
- Anti-Inflammatory Benefit: The system actively protects against the inflammatory stressors that damage hair follicles by suppressing apoptotic cues, resulting in a reported 30-fold reduction in scalp inflammation during lab testing.
- Clinical Results:Clinical studies from Yuvell, Aesthetic Clinic & Clinical Trial Center reported that subjects achieved a 20% to 30% increase in overall hair density and a 16% increase in hair shaft thickness after a 12-week course of treatment. Furthermore, internal studies documented a 15% increase in the number of follicles per square centimeter.
- Who It’s For: The system is ideal for women experiencing mild to moderate hair loss, including female-pattern hair loss (FPHL) and telogen effluvium. It has demonstrated excellent results even in patients previously unresponsive to traditional topical pharmaceutical agents.
CALECIM® vs. Traditional Therapies: A Comparison of Hair Restoration Options
Menopausal hair loss requires continuous management, and patients must weigh the efficacy, cost, and risk profiles of available treatments. The CALECIM® Advanced Hair System is positioned as an advanced, non-pharmaceutical, and highly tolerable alternative to standard drug-based and invasive procedures.
| Product | Pros | Cons |
| CALECIM® Advanced Hair System (PTT-6®) | It uses a drug-free regenerative mechanism. The system boasts a high safety profile, with no reported side effects. It significantly reduces scalp inflammation by a factor of 30. It is effective for patients unresponsive to Minoxidil. | It requires assisted delivery (derma stamper or microneedling) for optimal penetration. |
| Topical Minoxidil | It is a FDA-approved and affordable over-the-counter option. | It requires continuous use; results are reversed upon cessation. A common side effect is scalp irritation. |
| Oral Anti-Androgens | It addresses the hormonal cause by blocking DHT conversion. | It requires medical oversight. The potential systemic side effects include decreased libido, breast swelling/tenderness, and weight changes. |
| Platelet-Rich Plasma (PRP) Therapy | The therapy utilizes concentrated autologous growth factors derived from the patient’s own blood. | Invasive injectable procedure. High cost, ranging from $1,500 to $4,000 for a series of treatments. |
Step-by-Step Guide: Optimizing the CALECIM® Advanced Hair System Protocol
The Advanced Hair System protocol is designed to promote strong cell growth over 6 weeks and should be used with a gentle method such as microneedling, dermastamp, or roller to ensure that stem cell signals reach the skin layer.
Step 1: Prepare the Follicular Environment
What to do: Thoroughly cleanse the scalp to remove surface impurities, product buildup, and excess sebum. Use the provided activator to prep the scalp for maximal results.
Why: The menopausal scalp often suffers from barrier disruption and increased dryness. Proper cleansing and preparation establish a balanced, receptive environment, ensuring the PTT-6® complex can effectively communicate with hair follicle cells.
Step 2: Ensure Deep Delivery via Microneedling
What to do: Immediately following preparation, use a professional-grade microneedling device or derma stamper on the treatment area, then apply half an ampoule of the Advanced Hair System serum. This intensive treatment is performed twice per week for the initial 6-week course.
Why: The high concentration of growth factors and exosomes in PTT-6® requires physical assistance to penetrate the skin barrier. The creation of micro-channels ensures these regenerative bio-signals reach the Dermal Papilla Cells (DPCs), activating the hair cycle and accelerating follicle cell growth.
Step 3: Maintain Cellular Signaling
What to do: After completing the initial 6-week program ($360 USD per box), transition to a maintenance protocol, which typically involves applying the serum once per week with the derma stamper.
Why: As hair thinning during menopause is a chronic condition driven by continuous hormonal and ageing factors, continuous regenerative signalling is necessary to sustain the gains in density and thickness and prevent regression.
Why Menopausal Hormone Decline Requires a “Scalp Reset”
Menopausal hair loss (often manifesting as female pattern hair loss, or FPHL) is a complex physiological event where the declining levels of estrogen and progesterone compromise the entire follicular system. These hormonal changes lead to:
- Follicle Miniaturization: The loss of estrogen, which helps sustain the hair’s anagen phase, causes hair follicles to enter the telogen (resting/shedding) phase prematurely. The relative dominance of androgens, such as DHT, further shrinks the hair follicle, leading to finer, weaker, and more brittle hair.
- Compromised Scalp Microenvironment: Reduced hormones impair the health of blood vessels, limiting the supply of essential nutrients to the follicles. This results in scalp thinning, decreased moisture retention, and reduced sebum production, which further exacerbates dryness and breakage.
- Chronic Inflammation: Histological analysis frequently reveals perifollicular infiltration of inflammatory cells in FPHL patients. This chronic, low-grade inflammation signals apoptotic cues that accelerate the hair cycle and cause follicle cell death.
The CALECIM® Advanced Hair System provides a comprehensive “Scalp Reset.” Its PTT-6® complex acts as a potent anti-inflammatory agent, significantly reducing pathological stress in the scalp while simultaneously supplying the essential growth factors and proteins needed to stimulate DPC proliferation and overcome hormonal deficits at the cellular level. This dual action creates a stable, regenerative environment where density can be rebuilt.
Frequently Asked Questions (FAQs)
Q: Why does menopause cause hair thinning? A: The decrease in estrogen and progesterone shortens the hair’s growth cycle (anagen phase). This change also alters the balance between estrogen and male hormones, making male hormones like DHT more powerful, which causes hair follicles to shrink, a key sign of Female Pattern Hair Loss (FPHL).
Q: Is CALECIM® Advanced Hair System comparable to Minoxidil? A: CALECIM® works in a different way than drugs. It uses growth factors from stem cells and cellular signalling.
In vitro data confirmed that PTT-6® caused a 24.1% increase in dermal papilla cell growth, a result comparable to the DPC growth (24.5%) achieved with minoxidil at a concentration of 2ug/ml, suggesting similar DPC growth promotion effects.
Q: How soon can I expect results when using the Advanced Hair System? A: Patients often notice subjective improvements and reduced shedding around six weeks. Measurable results, including the reported 20-30% increase in density, typically become fully visible 3 to 6 months after starting the treatment course.
Clinical Evidence and Data
Scientific and clinical data support the efficacy of the CALECIM® Advanced Hair System:
- Clinical Efficacy (Density and Thickness): A 12-week prospective open-label case series involving patients with hair loss, conducted at the Yuvell Aesthetic Clinic, reported a 20% to 30% increase in hair density. Clinical observations also recorded a 16% increase in hair shaft thickness.
- Cellular Regeneration and Inflammation: Research published by the Singapore Polytechnic Department for Technology and Innovation demonstrated that PTT-6® caused a 1% increase in Dermal Papilla Cell growth. Furthermore, laboratory testing reported a 30-fold reduction in scalp inflammation.
- Safety Profile: Clinical case series have reported that the treatment was well tolerated by all participants, including those with sensitive skin, with no adverse effects or complications.
